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neurology

Zimmerman Scientists have been closing in on the specific molecular pathways that determine developmental fate. One focus of their attention is a fragment of embryonic tissue called the Spemann Organizer Signal noggin. This protein is secreted from the cells of the organizer and promotes dorsal cell fates in the Xenopus embryo. Noggin has the ability to bind to bone morphogenetic proteins (BMP) preventing it from becoming secured to its receptor. However, it remained unclear exactly if Noggin functioned as an antagonist to BMP4, if it had direct physical interaction with BMP4 and whether this mechanism could account for noggin’s recognition as a Spemann organizer signal. Does noggin work by binding to and interfering with the activi

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